Celldex Discontinues Barzolvolimab Development in Prurigo Nodularis After Phase 2 Failure
Celldex discontinues barzolvolimab development in prurigo nodularis after its Phase 2 study failed to meet the primary endpoint and key secondary endpoints.
Celldex discontinues barzolvolimab development in prurigo nodularis after its Phase 2 study failed to meet the primary endpoint and key secondary endpoints.
The acquisition would add a longer-acting alternative to Dupixent for inflammatory diseases.
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Wolfe Research upgrades Celldex Therapeutics to Outperform from Peer Perform, citing stronger 2026 catalysts and depressed valuation for rebound potential.
Celldex stopped barzolvolimab for eosinophilic esophagitis after it failed to improve symptoms, despite depleting mucosal mast cells. The company will now explore other GI diseases driven by mast cells where the antibody might be effective.